The sermon focuses on the story of Joseph in Genesis 40, emphasizing the importance of serving God wherever we find ourselves, even in difficult circumstances. Joseph, despite being imprisoned for a crime he did not commit, remains faithful and uses his God-given ability to interpret dreams to serve his fellow prisoners. The sermon draws parallels to modern-day examples, such as Chuck Colson, who found purpose in serving God during his prison time. The key message is that our circumstances should not dictate our faithfulness and that we are called to serve the King and His Kingdom in all situations.